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KMID : 1159320180200020119
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Korean Journal of Vision Science
2018 Volume.20 No. 2 p.119 ~ p.128
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The Influence of the 4 weeks Intake of Water-soluble Perilla frutescens var. acuta Extract on Refractive Error and Visual Function
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Jeong Kyeong-In
Kim Jae-Yong
Choi Chul-Yung
Seo Jeong-Seong
Seo Eun-Sun
Ryu Geun-Chang
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Abstract
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Purpose : The purpose of this study is to find how it influences on refractive error and visual function by intaking water soluble Perilla frutescens var. acuta (PFA) extract for 4 weeks.
Method : After the permission of the institutional review board of medical devices (IRB Permission No.: DSGOH-042), This study was tested on 30 adult men and women. Two hours after PFA or placebo was taken in, smart device based VDT work had been done for 2 hours. And then, the results before and after PFA intake were compared with those in control group.
Result : As a result, the PFA intake group tended to improve Spherical Equivalent Refractive Error statistically and significantly(p=0.001, p=0.000). Compared to the placebo intake group, the PFA intake group had statistically significant improvements in the near point of convergence and the near point of accommodation(p=0.007, p=0.001, p=0.001, p=0.000). According to the test on binocular accommodative facility, the PFA group showed a more significant rise after intake than before intake(p=0.021). The placebo group had no significant difference. Also, there was no significant difference between the two groups(p=0.876). After intake of PFA or placebo for 4 weeks, the safety before and after intake was evaluated. As a result, the two intake groups had no abnormal reaction. It was judged that taking in water-soluble PFA extract was safe to the human body.
Conclusion : PFA increased activity of ciliary body muscles more than placebo. Therefore, it is considered to suppress a rise in refractive error and to improve convergence, accommodation, and asthenopia.
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KEYWORD
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Extract of Perilla frutescens var. acuta, Refractive Error, Near Point of Convergence, Near Point of Accommodation, Binocular Accommodative Facility
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